Muscle insulin resistance in type 1 diabetes with coronary artery disease.
Katherine V WilliamsChristina M ShayJulie C PriceBret H GoodpasterCarol A KelleyDavid E KelleyTrevor John OrchardPublished in: Diabetologia (2020)
Our study confirms that systemic and skeletal muscle-specific insulin resistance is seen in type 1 diabetes but found that it does not appear to be more severe in the presence of CAD. There were, however, sharp differences between soleus and tibialis anterior muscles in type 1 diabetes: while insulin resistance was clearly manifest in soleus muscle, and was of equal severity in CAD+ and CAD- participants, tibialis anterior did not suggest insulin resistance in participants with type 1 diabetes, as FDG uptake by tibialis anterior correlated positively with CAC severity and was significantly increased in participants with type 1 diabetes and clinical CAD. Graphical abstract.
Keyphrases
- insulin resistance
- coronary artery disease
- type diabetes
- skeletal muscle
- glycemic control
- high fat diet
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- polycystic ovary syndrome
- metabolic syndrome
- adipose tissue
- high fat diet induced
- cardiovascular disease
- aortic stenosis
- pet imaging
- heart failure
- left ventricular
- computed tomography
- atrial fibrillation
- acute coronary syndrome