Pattern of failure in prostate cancer previously treated with radical prostatectomy and post-operative radiotherapy: a secondary analysis of two prospective studies using novel molecular imaging techniques.
Lindsay S RoweStephanie HarmonAdam HornUma ShankavaramSoumyajit RoyHolly NingLiza LindenbergEsther MenaDeborah E CitrinPeter ChoykeBaris TurkbeyPublished in: Radiation oncology (London, England) (2021)
18F-PSMA PET imaging demonstrates promise in identifying occult PCa recurrence after PORT. Although distant recurrence was the predominant pattern of failure, in-field recurrence was noted in approximately 1/5th of patients. This should be considered in tailoring radiotherapy practice after prostatectomy. Trial registration www.clinicaltrials.gov , NCT02190279 and NCT03181867. Registered July 12, 2014, https://clinicaltrials.gov/ct2/show/NCT02190279 and June 8 2017, https://clinicaltrials.gov/ct2/show/NCT03181867 .
Keyphrases
- radical prostatectomy
- prostate cancer
- pet imaging
- positron emission tomography
- early stage
- computed tomography
- newly diagnosed
- end stage renal disease
- image quality
- contrast enhanced
- radiation therapy
- locally advanced
- ejection fraction
- robot assisted
- radiation induced
- primary care
- magnetic resonance imaging
- healthcare
- dual energy
- clinical trial
- chronic kidney disease
- prognostic factors
- big data
- lymph node
- free survival
- squamous cell carcinoma
- patient reported outcomes
- quality improvement
- deep learning