AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation.

Deniz Uğurlu-ÇimenDeniz OdluyurtKenan SevinçNazlı Ezgi Özkan-KüçükBurcu ÖzçimenDeniz DemirtaşEray EnüstünCan AztekinMartin PhilpottUdo OppermannNurhan ÖzlüTamer T Önder

Published in: Epigenetics & chromatin (2021)

Our findings establish AF10 as a novel barrier to reprogramming by regulating H3K79 methylation and thereby sheds light on the mechanism by which cell identity is maintained in somatic cells.

Keyphrases

single cell
atrial fibrillation
cell therapy
induced apoptosis
dna methylation
genome wide
copy number
cell cycle arrest
stem cells
signaling pathway
oxidative stress
bone marrow
endoplasmic reticulum stress
pi k akt