Schlafen 11 Is a Novel Target for Mucosal Regeneration in Ulcerative Colitis.
Sho WatanabeRyu NishimuraTomoaki ShirasakiNobuhiro KatsukuraShuji HibiyaSusumu KirimuraMariko NegiRyuichi OkamotoYuka MatsumotoTetsuya NakamuraMamoru WatanabeKiichiro TsuchiyaPublished in: Journal of Crohn's & colitis (2022)
In vitro and in vivo UC-mimicking models were uniquely established using human colonic organoids. They revealed that SLFN11 is significant for mucosal injury in UC, and demonstrated its potential as a novel target for mucosal regeneration.