Efficacy of EGFR-TKIs with or without upfront brain radiotherapy for EGFR-mutant NSCLC patients with central nervous system metastases.

Yu SaidaSatoshi WatanabeTetsuya AbeSatoshi ShojiKoichiro NozakiKosuke IchikawaRie KondoKenichi KoyamaSatoru MiuraHiroshi TanakaMasaaki OkajimaMasaki TeradaTakashi IshidaHiroki TsukadaMasato MakinoAkira IwashimaKazuhiro SatoNaoya MatsumotoHirohisa YoshizawaToshiaki Kikuchi

Published in: Thoracic cancer (2019)

EGFR-TKI showed a favorable effect for EGFR-mutant NSCLC patients with CNS metastases. Prolonged TTF and CNS-PFS were observed with upfront brain radiotherapy.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
advanced non small cell lung cancer
early stage
brain metastases
white matter
locally advanced
radiation therapy
blood brain barrier
resting state
radiation induced
multiple sclerosis
wild type
cerebrospinal fluid
subarachnoid hemorrhage