SPIN(DLY)-OFF: A tale of conformational change to control DYNEIN.

João Barbosa Claudio E Sunkel Carlos Conde

Published in: The Journal of cell biology (2022)

Barbosa et al. discuss work by Mussachio and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202206131) finding that conformational changes in the DYNEIN adaptor SPINDLY can precisely control DYNEIN activation at kinetochores.

Keyphrases

single molecule
molecular dynamics
molecular dynamics simulations
single cell
room temperature
stem cells
bone marrow