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Persistent intrathecal interleukin-8 production in a patient with SARS-CoV-2-related encephalopathy presenting aphasia: a case report.

Takuya KudoYuichi HayashiKenjiro KuniedaNobuaki YoshikuraAkio KimuraMika OtsukiTakayoshi Shimohata
Published in: BMC neurology (2021)
The cytokine profile of our patient was similar to that seen in severe SARS-CoV-2-related encephalopathy. We demonstrated (i) that the characteristic aphasia can occur as a focal neurological deficit associated with SARS-CoV-2-related encephalopathy, and (ii) that IL8-mediated central nervous system inflammation follows systemic inflammation in SARS-CoV-2-related encephalopathy and can persist and worsen even after immunotherapy. Monitoring IL-8 in CSF, and long-term corticosteroids may be required for treating SARS-CoV-2-related encephalopathy.
Keyphrases
  • sars cov
  • early onset
  • respiratory syndrome coronavirus
  • case report
  • brain injury
  • subarachnoid hemorrhage
  • cerebrospinal fluid