Chemokine CXCL13 in serum, CSF and blood-CSF barrier function: evidence of compartment restriction.

Georg PilzIrma SakicPeter WipflerJörg KrausElisabeth Haschke-BecherWolfgang HitzlEugen TrinkaAndrea Harrer

Published in: Fluids and barriers of the CNS (2020)

We demonstrated that CXCL13 does not cross from blood into CSF, not even during severe BCSFB dysfunction. CSF CXCL13 elevations therefore most likely always are CNS-derived, which highlights their relevance as indicator of inflammatory CNS processes. We recommend data should not be corrected for BCSFB permeability (QAlb) and not to calculate CSF/serum quotients for CXCL13 as these may introduce error.

Keyphrases

oxidative stress
cerebrospinal fluid
blood brain barrier
early onset
electronic health record
machine learning
data analysis