Brain metabolic changes across King's stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-D-glucose-positron emission tomography study.

Antonio CanosaAndrea CalvoCristina MogliaUmberto ManeraRosario VastaFrancesca Di PedeSara CabrasDavide NardoVincenzo ArenaMaurizio GrassanoFabrizio D'OvidioKoen Van LaerePhilip Van DammeMarco PaganiAdriano Chiò

Published in: European journal of nuclear medicine and molecular imaging (2020)

Our findings support the hypothesis that in ALS, the propagation of neurodegeneration follows a corticofugal, regional ordered pattern, extending from the motor cortex to posterior and anterior regions.

Keyphrases

positron emission tomography
computed tomography
pet ct
pet imaging

white matter
type diabetes
resting state
metabolic syndrome

blood glucose
multiple sclerosis
blood pressure
insulin resistance

skeletal muscle
functional connectivity
blood brain barrier
cerebral ischemia