Tumor Volume Growth Rates and Doubling Times during Active Surveillance of IDH-mutant Low-Grade Glioma.

Ankush Bhatia Raquel Andrade Moreno Anne S Reiner Subhiksha Nandakumar Henry S Walch Teena M Thomas Philip J Nicklin Ye Choi Anna Skakodub Rachna Malani Vivek Prabhakaran Pallavi Tiwari Maria Diaz Katherine S Panageas Ingo K Mellinghoff Tejus A Bale Robert J Young

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

TVGR may be used as an earlier measure of clinical benefit and correlates well with the WHO 2021 molecular classification of gliomas and survival. Incorporation of TVGR as a surrogate endpoint into future prospective studies of IDH-mt gliomas may accelerate drug development.

Keyphrases

low grade
high grade
machine learning
deep learning
current status
wild type
case control
free survival
single molecule