Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling.

Wenming LiWenhao LiWei ZhangHongzhi WangLei YuPeng YangYi QinMinfeng GanXing YangLixin HuangYuefeng HaoDechun Geng

Published in: Stem cell research & therapy (2023)

We proposed that MT attenuated SONFH by inhibiting ferroptosis through the regulation of GDF15, and supplementation with exogenous MT might be a promising method for the treatment of SONFH.

Keyphrases

cell death
signaling pathway
high glucose
diabetic rats
mouse model
drug induced
endothelial cells
replacement therapy