Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats.
Oluwayemisi B IbitoyeTaofeek Olakunle AjiboyePublished in: Archives of physiology and biochemistry (2017)
This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on high-fructose diet-induced metabolic syndrome in rats. Oral administration of the phenolic acids significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, phenolic acids restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Similarly, elevated tumour necrosis factor-α, interleukin-6 and -8 were significantly lowered. Administration of phenolic acids restored High-fructose diet-mediated increase in the levels of lipid parameters and indices of atherosclerosis, cardiac and cardiovascular diseases. High-fructose diet-mediated decrease in activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase) and increase in oxidative stress biomarkers (reduced glutathione, lipid peroxidation products, protein oxidation and fragmented DNA) were significantly restored by the phenolic acids. The result of this study shows protective influence of caffeic acid, ferulic acid, gallic acid and protocatechuic acid in high-fructose diet-induced metabolic syndrome.
Keyphrases
- metabolic syndrome
- oxidative stress
- insulin resistance
- blood glucose
- cardiovascular disease
- physical activity
- weight loss
- type diabetes
- hydrogen peroxide
- heart failure
- adipose tissue
- skeletal muscle
- nitric oxide
- cardiovascular risk factors
- mass spectrometry
- high resolution
- coronary artery disease
- polycystic ovary syndrome
- diabetic rats
- ischemia reperfusion injury
- endoplasmic reticulum stress
- protein protein