Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response.
Wenhao ZhangWytske M van WeerdenCorrina M A de RidderSigrun Erkens-SchulzeEdgar SchönfeldTitia G MeijerRoland KanaarDik C van GentJulie NonnekensPublished in: The Prostate (2018)
Ex vivo treatment of PCa PDX tumor slices with enzalutamide and olaparib recapitulates responses previously observed in vivo. The faithful retention of tissue structure and function in this ex vivo model offers an ideal opportunity for treatment efficacy screening, thereby reducing costs and numbers of experimental animals.