Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment.

Yuyi ChenJie ZhouZishen LiuTongtong WuShumeng LiYutong ZhangXiaohui YinGuo-Wang YangGanlin Zhang

Published in: Journal of experimental & clinical cancer research : CR (2023)

TCIPA accelerates MM lung metastasis via tumor-educated platelets (TEPs), triggering TAM recruitment, promoting TAM polarization (M2), and remodeling the suppressive TIME in lung metastases.

Keyphrases

single cell
high glucose
adipose tissue
diabetic rats
drug induced
endothelial cells
mesenchymal stem cells
bone marrow