Streptocinnamides A and B, Depsipeptides from Streptomyces sp. KMM 9044.
Tatyana N MakarievaLyudmila A RomanenkoKonstantin S MineevLarisa K ShubinaElena B GuglyaNatalia I KalinovskayaNatalia V IvanchinaAlla G GuziiOlga A BelozerovaSergey I KovalchukRoman S PopovVladimir A DenisenkoValery V MikhailovVladislav V BabenkoElena N IlinaMaja V MalakhovaStanislav S TerekhovArsen M KudzhaevPavel S DmitrenokIlia V YampolskyValentin A StonikPublished in: Organic letters (2022)
The bacterium Streptomyces sp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A ( 1 ) and B ( 2 ), representatives of a new structural group of antibiotics. The structures of 1 and 2 were determined using nuclear magnetic resonance and mass spectrometry studies and confirmed by a series of chemical transformations. Streptocinnamide A potently inhibits Micrococcus sp. KMM 1467, Arthrobacter sp. ATCC 21022, and Mycobacterium smegmatis MC2 155.