Investigation of Monogenic Diabetes Genes in Thai Children with Autoantibody Negative Diabetes Requiring Insulin.
Nipaporn TeerawattanapongThanida TangjarusritaratornTassanee NarkdontriJeerunda SantiprabhobWatip TangjittipokinPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2024)
This study demonstrated significant genetic overlap between autoantibody-negative diabetes and monogenic diabetes using WES. All candidate variants were considered disease risk with clinically significant variants. WES screening was the first implemented to diagnose monogenic diabetes in Thai children, and fourteen novel variants were identified in this study and need to be investigated in the future.