Occupational exposure to 50 ppm isoflurane impairs sperm parameters in mice.

Marina Zanin Antonio Sergio Varela Junior Izani Bonel Acosta Edenara Anastacio da Silva Maria Eduarda Bicca Dode Martielo Ivan Gehrcke Mariana Gobbo Braz Carine Dahl Corcini

Published in: Journal of occupational and environmental medicine (2024)

Isoflurane at 50 ppm, previously deemed safe by some countries, impairs sperm kinetics and viability, potentially directing the spermatogenic process towards infertility and apoptosis.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
high fat diet induced
polycystic ovary syndrome
insulin resistance
wild type
skeletal muscle
pi k akt
signaling pathway