Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke.
Pang-Shuo HuangJen-Fang ChengGuan-Wei LiEric Y ChuangJien-Jiun ChenFu-Chun ChiuCho-Kai WuYi-Chih WangJuey-Jen HwangChia-Ti TsaiPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
We found a link between the homozygous deletion of the GSDMD gene and an increased risk of stroke in patients with AF. This may implicate the use of therapy targeting GSDMD in the prevention of ischaemic stroke for AF patients.
Keyphrases
- atrial fibrillation
- copy number
- mitochondrial dna
- genome wide
- oral anticoagulants
- left atrial
- catheter ablation
- left atrial appendage
- direct oral anticoagulants
- end stage renal disease
- heart failure
- dna methylation
- newly diagnosed
- ejection fraction
- prognostic factors
- percutaneous coronary intervention
- cancer therapy
- coronary artery disease
- peritoneal dialysis
- gene expression
- chronic kidney disease
- drug delivery
- mesenchymal stem cells
- transcription factor