Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke.
Pengfei YangYongwei ZhangLei ZhangYongxin ZhangKilian M TreurnietWenhuo ChenYa PengHongxing HanJiyue WangShouchun WangCongguo YinSheng LiuPeng WangQi FangHongchao ShiJianhong YangChangming WenConghui LiChangchun JiangJun SunXincan YueMin LouMeng ZhangHansheng ShuDianjing SunHui LiangTong LiFuqiang GuoKaifu KeHaicheng YuanGuoping WangWeimin YangHuaizhang ShiTianxiao LiZifu LiPengfei XingPing ZhangYu ZhouHao WangYi XuQinghai HuangTao WuRui ZhaoQiang LiYibin FangLaixing WangJianping LuYansheng LiJianhui FuXihua ZhongYongjun WangLongde WangMayank GoyalDiederik W J DippelBo HongBenqiang DengYvo B W E M RoosCharles B L M MajoieJianmin Liunull nullPublished in: The New England journal of medicine (2020)
In Chinese patients with acute ischemic stroke from large-vessel occlusion, endovascular thrombectomy alone was noninferior with regard to functional outcome, within a 20% margin of confidence, to endovascular thrombectomy preceded by intravenous alteplase administered within 4.5 hours after symptom onset. (Funded by the Stroke Prevention Project of the National Health Commission of the People's Republic of China and the Wu Jieping Medical Foundation; DIRECT-MT ClinicalTrials.gov number, NCT03469206.).