Allomyrina dichotoma larva extract attenuates free fatty acid-induced lipotoxicity in pancreatic beta cells.

Kyong Kim Min-Kyu Kwak Gong-Deuk Bae Eun-Young Park Dong-Jae Baek Chul-Young Kim Se-Eun Jang Yoon Sin Oh Yoon Sin Oh

Published in: Nutrition research and practice (2021)

ADLE helps prevent lipotoxic beta-cell death in INS-1 cells and HFD-diabetic mice, suggesting that ADLE can be used to prevent or treat beta-cell damage in glucose intolerance during the development of diabetes.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
oxidative stress
cardiovascular disease
endoplasmic reticulum stress
stem cells
high fat diet
signaling pathway
pi k akt
cell proliferation
blood pressure
mesenchymal stem cells
adipose tissue
blood glucose
weight loss
anti inflammatory