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Structural investigation of methyl 3-(4-fluoro-benzo-yl)-7-methyl-2-phenyl-indolizine-1-carboxyl-ate, an inhibitory drug towards Mycobacterium tuberculosis.

Avantika HasijaSubhrajyoti BhandaryKatharigatta Narayanaswamy VenugopalaSandeep ChandrashekharappaDeepak Chopra
Published in: Acta crystallographica. Section E, Crystallographic communications (2020)
The title compound, C24H18FNO3, crystallizes in the monoclinic centrosymmetric space group P21/n and its mol-ecular conformation is stabilized via C-H⋯O intra-molecular inter-actions. The supra-molecular network mainly comprises C-H⋯O, C-H⋯F and C-H⋯π inter-actions, which contribute towards the formation of the crystal structure. The different inter-molecular inter-actions have been further analysed via Hirshfeld surface analysis and fingerprint plots.
Keyphrases
  • crystal structure
  • mycobacterium tuberculosis
  • single molecule
  • positron emission tomography
  • pulmonary tuberculosis
  • adverse drug