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Expression Profile of Pyroptosis-Related Genes and the Associated Regulatory Axis in Primary Gout Patients.

Shaowei NiuTian-Yi LeiFei DaiHongyuan XieXiang YuQuanbo ZhangYu-Feng Qing
Published in: Journal of inflammation research (2023)
There are several differentially expressed PRGs in PBMCs of gout patients, which are involved in the regulation of gout inflammation through multiple pathways. hsa_circRNA_102911-hsa-miR-129-5p-DDX3X\NLRP3\NLRP9 may be the key regulatory pathway for pyroptosis to regulate gout inflammation, and hsa_circRNA_102911 may be a potential biomarker for the diagnosis of primary gout.
Keyphrases
  • uric acid
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • oxidative stress
  • prognostic factors
  • metabolic syndrome
  • transcription factor