Expression Profile of Pyroptosis-Related Genes and the Associated Regulatory Axis in Primary Gout Patients.

Shaowei NiuTian-Yi LeiFei DaiHongyuan XieXiang YuQuanbo ZhangYu-Feng Qing

Published in: Journal of inflammation research (2023)

There are several differentially expressed PRGs in PBMCs of gout patients, which are involved in the regulation of gout inflammation through multiple pathways. hsa_circRNA_102911-hsa-miR-129-5p-DDX3X\NLRP3\NLRP9 may be the key regulatory pathway for pyroptosis to regulate gout inflammation, and hsa_circRNA_102911 may be a potential biomarker for the diagnosis of primary gout.

Keyphrases

uric acid
end stage renal disease
ejection fraction
newly diagnosed
oxidative stress
prognostic factors
metabolic syndrome
transcription factor