Sleep-associated insulin resistance promotes neurodegeneration.
Kanagavalli RamasubbuGnanasambandan RamanathanGanesh VenkatramanVijayarangan Devi RajeswariPublished in: Molecular biology reports (2023)
Lifestyle modification can lead to numerous health issues closely associated with sleep. Sleep deprivation and disturbances significantly affect inflammation, immunity, neurodegeneration, cognitive depletion, memory impairment, neuroplasticity, and insulin resistance. Sleep significantly impacts brain and memory formation, toxin excretion, hormonal function, metabolism, and motor and cognitive functions. Sleep restriction associated with insulin resistance affects these functions by interfering with the insulin signalling pathway, neurotransmission, inflammatory pathways, and plasticity of neurons. So, in this review, We discuss the evidence that suggests that neurodegeneration occurs via sleep and is associated with insulin resistance, along with the insulin signalling pathways involved in neurodegeneration and neuroplasticity, while exploring the role of hormones in these conditions.
Keyphrases
- insulin resistance
- type diabetes
- physical activity
- sleep quality
- metabolic syndrome
- polycystic ovary syndrome
- adipose tissue
- high fat diet
- oxidative stress
- healthcare
- glycemic control
- cardiovascular disease
- escherichia coli
- public health
- high fat diet induced
- spinal cord
- mental health
- multiple sclerosis
- spinal cord injury
- weight loss
- brain injury
- social media
- climate change
- blood brain barrier
- health promotion