Non-Rapid Eye Movement Sleep Features in Post-Stroke Human Electroencephalogram.

These findings suggest that, acutely post-stroke, pathological δ waves increase in the human brain and that spindle density may be impacted by drugs that modulate excitatory/inhibitory neural transmission. Further, we found that drugs that increase inhibitory transmission or curb excitation promote pathological δ wave-nested spindles. Our results indicate that factoring in pharmacologic drugs may be important when targeting sleep modulation for neurorehabilitation.