Cytopathological assessment is an accurate method for identifying immunophenotypic features and BRCA1/2 mutations of high-grade serous carcinoma from ascites.
Simona MiceskaErik ŠkofSrdjan NovakovićVida StegelAnja JeričevićBiljana Grčar KuzmanovŠpela SmrkoljBranko CvjetičaninSonja BebarMarta Globočnik KukovicaVeronika Kloboves PrevodnikPublished in: Cancer cytopathology (2022)
These results demonstrate that cytopathology is an accurate method for identifying immunophenotypic features of HGSC and detecting germline BRCA1/2 mutations from ascites. However, further investigation is required for assessing the proliferation activity of HGSC in ascites and for detecting somatic BRCA1/2 mutations.