CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia.
Samir Abu-RumeilehPetra SteinackerBarbara PolischiAngela MammanaAnna Bartoletti-StellaPatrick OecklSimone BaiardiCorrado ZenesiniAndré HussPietro CortelliSabina CapellariMarkus OttoPiero ParchiPublished in: Alzheimer's research & therapy (2019)
NDs share a CSF profile characterized by increased levels of CSF CHIT1, YKL-40, and GFAP, which likely reflects a common neuroinflammatory response to protein misfolding and aggregation. CSF glial markers of neuroinflammation demonstrate limited diagnostic value but have some potential for monitoring the clinical and, possibly, preclinical phases of NDs.
Keyphrases
- cognitive impairment
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- cerebrospinal fluid
- mild cognitive impairment
- cerebral ischemia
- stem cells
- inflammatory response
- risk assessment
- spinal cord injury
- small molecule
- neuropathic pain
- bone marrow
- cell therapy
- human health
- mesenchymal stem cells
- binding protein