Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers.

Palang ChotsiriThanaporn WattanakulRichard M HoglundBorimas HanboonkunupakarnSasithon PukrittayakameeDaniel BlessbornPodjanee JittamalaNicholas J WhiteNicholas P J DayJoel Tarning

Published in: British journal of clinical pharmacology (2017)

Pharmacokinetic-pharmacodynamic modelling and simulation in healthy adult volunteers suggested that therapeutic doses of DHA-piperaquine in the prevention or treatment of P. falciparum malaria are unlikely to be associated with dangerous QT prolongation.

Keyphrases

plasmodium falciparum
drug administration
drug induced
left ventricular
heart failure
replacement therapy
virtual reality