Deubiquitinating enzyme USP10 promotes osteosarcoma metastasis and epithelial-mesenchymal transition by stabilizing YAP1.

Jianyong DengXuan YiZuxi FengJie PengDan LiChen LiBinbin DengShuaigang LiuSouradeep SahuLiang Hao

Published in: Cancer medicine (2023)

Together, this study showed that USP10 can directly interact with YAP1 to reduce ubiquitinated YAP1, thereby stabilizing its protein levels and affecting EMT and distant metastasis in OS cells.

Keyphrases

epithelial mesenchymal transition
induced apoptosis
signaling pathway
transforming growth factor
cell cycle arrest
lymph node
endoplasmic reticulum stress
binding protein
amino acid