Epigenomic signature of major congenital heart defects in newborns with Down syndrome.

Julia S MouatShaobo LiSwe Swe MyintBenjamin I LauferPhilip J LupoJeremy M SchrawJohn P WoodhouseAdam J de SmithJanine M LaSalle

Published in: medRxiv : the preprint server for health sciences (2023)

A sex-specific signature of DNA methylation was detected in NDBS of DS-CHD compared to DS non-CHD individuals. This supports the hypothesis that epigenetics can reflect the variability of phenotypes in DS, particularly CHDs.

Keyphrases

dna methylation
gene expression
pregnant women
genome wide
low birth weight
gestational age
preterm birth