First-line antituberculosis drug concentrations in infants with HIV and a history of recent admission with severe pneumonia.

Chishala ChabalaTom G JacobsCinta MoraledaJohn M NdaferankhandeVivian MumbiroAlfeu PassanducaNatasha NamuziyaDamalie NalwangaVictor MusiimeAlvaro BallesterosSara Domínguez-RodríguezMoses ChitsamatangaUneisse CassiaBwendo NdunaJustina BramugyJahit SacarlalLola MadridKusum J NathooAngela ColbersDavid M BurgerVeronica MulengaW Chris BuckHilda A MujuruLindsey H M Te BrakePablo RojoAlfredo TagarroRob E Aarnoutsenull null

Published in: Journal of the Pediatric Infectious Diseases Society (2023)

Optimal antituberculosis therapy is essential for favourable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared to reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
drug induced
mycobacterium tuberculosis
early onset
extracorporeal membrane oxygenation
acute respiratory distress syndrome
cell therapy
mechanical ventilation