Efficacy and safety of tumor necrosis factor inhibitors for systemic juvenile idiopathic arthritis: a systematic review.
Takashi IshikawaKenichi NishimuraNami OkamotoKeiji AkamineNatsumi InoueHitoshi IrabuKentaro KatoHiroshi KeinoMasayo KojimaHiroshi KuboKazuichi MaruyamaMao MizutaKosuke ShabanaMasaki ShimizuYuko SugitaYukiko TakakuwaSatoshi TakanashiHiroshi TakaseHiroaki UmebayashiNatsuka UmezawaShingo YamanishiKazuko YamazakiMasato YashiroTakahiro YasumiMasaaki MoriPublished in: Modern rheumatology (2024)
Thus, although TNF inhibitors were relatively safe, they were unlikely to be preferentially administered in patients with systemic JIA because of their inadequate efficacy. Further studies, particularly well-designed RCTs, are necessary to confirm the efficacy and safety of TNF inhibitors for systemic JIA.