Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient-derived xenografts.

Regina RabAnnette EhrhardtBhagelu R AchyutDisha JoshiMelissa Gilbert-RossChunzi HuangKatharine FloydAnton V BorovjaginWilliam B ParkerEric J SorscherJeong S Hong

Published in: Cancer reports (Hoboken, N.J.) (2022)

Our studies provide the scientific foundation necessary to improve PNP prodrug cleavage and advance a new treatment for head and neck cancer.

Keyphrases

escherichia coli
cancer therapy
combination therapy
klebsiella pneumoniae
drug delivery
smoking cessation