Left Main Coronary Artery Calcium and Diabetes Confer Very-High-Risk Equivalence in Coronary Artery Calcium >1,000.
Alexander C RazaviLeslee J ShawDaniel S BermanMatthew J BudoffNathan D WongViola VaccarinoMarly van AssenCarlo N De CeccoArshed A QuyyumiAnurag MehtaPaul MuntnerMichael D MiedemaAlan RozanskiJohn A RumbergerKhurram NasirRoger S BlumenthalLaurence S SperlingMartin Bødtker MortensenSeamus P WheltonMichael J BlahaOmar DzayePublished in: JACC. Cardiovascular imaging (2024)
Among asymptomatic patients with a CAC of ≥1,000 without a prior index event, diabetes, and severe LM CAC define very high risk ASCVD, identifying individuals who may benefit from more intensive prevention therapies across several domains, including low-density lipoprotein-cholesterol lowering.