The impact of statin discontinuation and restarting rates on the optimal time to initiate statins and on the number of cardiovascular events prevented.

Alexander PateRachel A ElliottGeorgios GkountourasAlexander ThompsonRichard EmsleyTjeerd van Staa

Published in: Pharmacoepidemiology and drug safety (2020)

In certain scenarios, extra cardiovascular disease events could be prevented by delaying statin initiation beyond a risk of 10% until reaching a age (59 for men, 63 for women), based on statin discontinuation rates in England. The optimal time to initiate statins was driven by age, not by cardiovascular risk.

Keyphrases

cardiovascular disease
cardiovascular events
coronary artery disease
type diabetes
cardiovascular risk factors
climate change
polycystic ovary syndrome
pregnancy outcomes
metabolic syndrome
low density lipoprotein