A Tough Polysaccharide-Based Hydrogel with an On-Demand Dissolution Feature for Chronic Wound Care through Light-Induced Ultrafast Degradation.
Ning CuiKai HanChuqing ZhouMinho SeongTingli LuHoon Eui JeongPublished in: ACS applied bio materials (2020)
Repeatedly changing dressings during wound healing can cause unbearable physical pain for patients with chronic skin injury. In this study, we designed a tough hydrogel-based dressing that can be degraded in an on-demand fashion for advanced chronic wound care. The resultant hydrogel dressing could be rapidly dissolved within 100 s after wetting with lithium phenyl(2,4,6-trimethylbenzonyl)phosphinate solution under low-power (1 W) ultraviolet (UV) irradiation (365 nm) owing to the breakage of disulfide bonds. This UV-triggered on-demand dissolution of tough hydrogels allows for a facile dressing replacement without causing tissue damage or pain, which is of great potential for clinical utilization.
Keyphrases
- wound healing
- pain management
- chronic pain
- healthcare
- palliative care
- neuropathic pain
- quality improvement
- machine learning
- physical activity
- mental health
- affordable care act
- oxidative stress
- deep learning
- drug delivery
- solid state
- radiation therapy
- highly efficient
- gold nanoparticles
- aqueous solution
- hyaluronic acid
- climate change
- soft tissue
- reduced graphene oxide