The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.
Zhenshan WangYanfen ZhouDong YangTingrong ChenXinxia LiuShujuan LiZhenshan WangPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
In AC3-/- mice, innervation of the lamina propria in the colonic mucosa was reduced and colonic propulsion was accelerated. AC3 is crucial for the development and function of the adult neural network of ENS. AC3 deficiency caused atrophy in the colonic mucosal neural network of mice.