IgG3 + B cells are associated with the development of multiple sclerosis.
Felix Marsh-WakefieldThomas Myles AshhurstStephanie TrendHelen Marie McGuirePierre JuillardAnna ZingerAnderson P JonesAllan G KermodeSimon HawkeGeorges E GrauPrue H HartScott N ByrnePublished in: Clinical & translational immunology (2020)
We have identified previously uncharacterised subsets of IgG3 + B cells and shown them to correlate with autoimmune attacks on the central nervous system (CNS). These results highlight the potential for therapies that specifically target IgG3 + B cells to impact MS progression.