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In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4+ TH1 cell response.

Aurélien Sutra Del GalySilvia MenegattiJaime FuentealbaFrancesca LucibelloLaetitia PerrinJulie HelftAurélie DarboisMichael SaitakisJimena ToselloDerek RookhuizenMarc DelogerPierre GestraudGerard SocièSebastian AmigorenaOlivier LantzLaurie Menger
Published in: Science immunology (2021)
[Figure: see text].
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • single cell
  • dna damage
  • cell therapy
  • cell cycle
  • smoking cessation
  • high throughput
  • gene expression
  • stem cells
  • mesenchymal stem cells
  • oxidative stress