Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics.
Christian Griñán-FerréJúlia Jarné-FerrerAina Bellver-SanchísSandra CodonyDolors Puigoriol-IllamolaCoral SanfeliuYumin OhSeulki LeeSantiago VázquezMercé PallàsPublished in: CNS neuroscience & therapeutics (2023)
In whole, our results support the concept that targeting neuroinflammation through sEH inhibition is a promising therapeutic strategy to fight against Alzheimer's disease with additive and/or synergistic activities targeting neuroinflammation and cell stress.