The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System.
Dionysios V ChartoumpekisPanos G ZirosIlias Georgakopoulos-SoaresAdam Alexander Thil SmithAna Claudia MarquesMark IbbersonPeter A KoppIoannis HabeosIoannis P TrougakosNicholas K H KhooGerasimos P SykiotisPublished in: Antioxidants (Basel, Switzerland) (2020)
Iodide overload induces the Nrf2 cytoprotective response and upregulates inflammatory, immune, and fibrosis pathways similar to autoimmune hyperthyroidism (Graves' disease) and PTC.