Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities.

Jian LinYuting DaiChen SangGuohe SongBin XiangMao ZhangLiangqing DongXiaoli XiaJiaqiang MaXia ShenShuyi JiShu ZhangMingjie WangHai FangXiaoming ZhangXiangdong WangBing ZhangJian ZhouJia FanHu ZhouDaming GaoQiang Gao

Published in: Journal for immunotherapy of cancer (2022)

Our study elucidates that the immunogenomic traits of iCCA are intrinsically heterogeneous among patients, posing great challenge and opportunity for the application of personalized immunotherapy.

Keyphrases

gene expression
dna methylation