Preliminary radiogenomic study of hepatitis B virus-related hepatocellular carcinoma: associations between MRI features and mutations.
Shanshan GaoFeihang WangWei SunXianling QianYuan JiYunfeng ChengXiaolin WangLingxiao LiuMengsu ZengMengsu ZengPublished in: Personalized medicine (2023)
Aim: To investigate associations between MRI features and high-frequency mutations of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods: This study included 58 HCC patients who underwent contrast-enhanced MRI prior to surgical resection and genome sequencing. MRI features and mutation information were evaluated. Results: The top five most frequently mutated genes in HCC were TP53 (53.45%), TAF1 (24.14%), PDE4DIP (22.41%), ABCA13 (18.97%) and LRP1B (17.24%). Mutations in TP53 and LRP1B were associated with tumor necrosis (p = 0.035) and mosaic architecture (p = 0.015), respectively. Mutations in ABCA13 were associated with mosaic architecture (p = 0.025) and necrosis (p = 0.010). Conclusion: This preliminary radiogenomics analysis showed associations between MRI features and high-frequency mutations in HBV-related HCCs.
Keyphrases
- hepatitis b virus
- contrast enhanced
- high frequency
- magnetic resonance imaging
- diffusion weighted
- diffusion weighted imaging
- magnetic resonance
- transcranial magnetic stimulation
- computed tomography
- liver failure
- end stage renal disease
- newly diagnosed
- ejection fraction
- genome wide
- healthcare
- peritoneal dialysis
- dual energy
- prognostic factors
- data analysis