Integrating 31-Gene Expression Profiling With Clinicopathologic Features to Optimize Cutaneous Melanoma Sentinel Lymph Node Metastasis Prediction.
Eric D WhitmanVadim P KoshenkovBrian R GastmanDeri LewisEddy C HsuehHo PakThomas P TrezonaRobert S DavidsonMichael McPheeJ Michael GuentherPaul ToomeyFranz O SmithPeter D BeitschJames M LewisAndrew WardShawn E YoungParth K ShahAnn P QuickBrian J MartinOlga ZolochevskaKyle R CovingtonFederico A MonzonMatthew S GoldbergRobert W CookMartin D FlemingDavid M HyamsJohn T VettoPublished in: JCO precision oncology (2021)
These data suggest the i31-GEP could reduce the number of SLNBs performed by identifying patients with likelihood under the 5% threshold for performance of SLNB and improve the yield of positive SLNBs by identifying patients more likely to have a positive SLNB.