Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains.
Ana Carolina Justino de AraújoPriscilla Ramos FreitasIsaac Moura AraújoGustavo Miguel SiqueiraJoão Arthur de Oliveira BorgesDaniel Sampaio AlvesGustavo Marinho MirandaIgor José Dos Santos NascimentoJoão Xavier de Araújo-JúniorEdeildo Ferreira da Silva-JúniorThiago Mendonça de AquinoFrancisco Jaime Bezerra Mendonça JuniorEmanuel Silva MarinhoHelcio Silva Dos SantosSaulo Relison TintinoHenrique Doouglas Melo CoutinhoPublished in: Fundamental & clinical pharmacology (2023)
Among all the results obtained in the study, the relevance of thiadiazine analogs as possible coadjuvant drugs in the antibacterial, anti-inflammatory, and neurological action with low toxicity is clear. Need for further studies to verify these effects in living organisms is not ruled out.