Clinical and virological features of acute hepatitis E in Gunma prefecture, Japan between 2004 and 2015.
Yuichi YamazakiAtsushi NaganumaYosuke AraiSuguru TakeuchiTakeshi KobayashiSatoshi TakakusagiTakeshi HatanakaTakashi HoshinoMasashi NamikawaHiroaki HashizumeDaichi TakizawaTatsuya OhyamaHideyuki SuzukiNorio HoriguchiHitoshi TakagiKen SatoSatoru KakizakiMotoyasu KusanoShigeo NagashimaMasaharu TakahashiHiroaki OkamotoMasanobu YamadaPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2016)
Markedly divergent HEV strains (3a, 3b, 3e and 3f) were found to circulate in Gunma. Although immunosuppression appears to play a crucial role in establishing chronic sequels, AH-E in eight immunocompromised patients, including transfusion-transmitted HEV infection in two patients, did not become chronic.