Recent Progress in the Development of Indole-Based Compounds Active against Malaria, Trypanosomiasis and Leishmaniasis.
Paulo A F PachecoMaria M M SantosPublished in: Molecules (Basel, Switzerland) (2022)
Human protozoan diseases represent a serious health problem worldwide, affecting mainly people in social and economic vulnerability. These diseases have attracted little investment in drug discovery, which is reflected in the limited available therapeutic arsenal. Authorized drugs present problems such as low efficacy in some stages of the disease or toxicity, which result in undesirable side effects and treatment abandonment. Moreover, the emergence of drug-resistant parasite strains makes necessary an even greater effort to develop safe and effective antiparasitic agents. Among the chemotypes investigated for parasitic diseases, the indole nucleus has emerged as a privileged molecular scaffold for the generation of new drug candidates. In this review, the authors provide an overview of the indole-based compounds developed against important parasitic diseases, namely malaria, trypanosomiasis and leishmaniasis, by focusing on the design, optimization and synthesis of the most relevant synthetic indole scaffolds recently reported.
Keyphrases
- drug resistant
- drug discovery
- mental health
- healthcare
- plasmodium falciparum
- multidrug resistant
- endothelial cells
- acinetobacter baumannii
- public health
- escherichia coli
- climate change
- emergency department
- oxidative stress
- tissue engineering
- cystic fibrosis
- social media
- drug induced
- pseudomonas aeruginosa
- electronic health record
- toxoplasma gondii
- induced pluripotent stem cells
- replacement therapy