Design and development of a photoswitchable DFG-out kinase inhibitor.

Yongjin XuChunxia GaoLiliana HåversenThomas Lundbäck Joakim Andréasson Morten Grøtli

Published in: Chemical communications (Cambridge, England) (2021)

We report the synthesis and characterisation of a photoswitchable DFG-out kinase inhibitor. Photocontrol of the target kinase in both enzymatic and living cell assays is demonstrated.

Keyphrases

single cell
cell therapy
high throughput
hydrogen peroxide
mesenchymal stem cells
nitric oxide