Empirical use of β-lactam/β-lactamase inhibitor combinations does not increase mortality compared with cloxacillin and cefazolin in methicillin-susceptible Staphylococcus aureus bacteraemia: a propensity-weighted cohort study.
Rein WillekensMireia Puig-AsensioPaula SuanzesNuria Fernández-HidalgoMaria N LarrosaJuan J González-LópezDolors Rodríguez-PardoCarles PigrauBenito AlmirantePublished in: The Journal of antimicrobial chemotherapy (2022)
BL/BLICs might be an effective empirical treatment for MSSA bacteraemia when de-escalated to cloxacillin or cefazolin within 96 h from the index blood culture.
Keyphrases
- staphylococcus aureus
- escherichia coli
- gram negative
- methicillin resistant staphylococcus aureus
- magnetic resonance
- biofilm formation
- multidrug resistant
- cardiovascular events
- klebsiella pneumoniae
- risk factors
- computed tomography
- combination therapy
- magnetic resonance imaging
- pseudomonas aeruginosa
- replacement therapy