Airborne particulate matters induce thrombopoiesis from megakaryocytes through regulating mitochondrial oxidative phosphorylation.
Xiaoting JinHongyan YuBaoqiang WangZhendong SunZe ZhangQian S LiuYuxin ZhengQunfang ZhouGuibin JiangPublished in: Particle and fibre toxicology (2021)
The findings for the first time unveil the potential perturbation of haze exposure in thrombopoiesis from megakaryocytes by regulating mitochondrial OXPHOS. The substantial evidence on haze particle-incurred hematotoxicity obtained herein provided new insights for assessing the hazardous health risks from PM pollution.