Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma.

Andrew TeoLouisa L Y ChanChristine CheungPo Ying ChiaSean Wei Xiang OngSiew Wai FongLisa F P NgLaurent ReniaDavid Chien LyeBarnaby Edward YoungTsin Wen Yeo

Published in: Communications medicine (2023)

Neutrophil MPO may increase EG shedding in COVID-19, and inhibiting MPO activity may protect against EG degradation. Further research is needed to evaluate the utility of MPO inhibitors as potential therapeutics against severe COVID-19.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
small molecule
endothelial cells
risk assessment
human health